It’s better to just stay on the protocol.
Your body won’t understand what you’re trying to do when you put exogenous hormones and try to produce endogenous hormones at the same time.
It’s better to just stay on the protocol.
Your body won’t understand what you’re trying to do when you put exogenous hormones and try to produce endogenous hormones at the same time.
Total Male Optimization "People who say it can't be done shouldn't interrupt those that are doing it"
Minoxidil inhibits androgen receptors and also decreases expression of 5-alpha reductase II
Minoxidil may suppress androgen receptor-related functions
Minoxidil Acts as an Antiandrogen: A Study of 5α-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line - PubMed
Total Male Optimization "People who say it can't be done shouldn't interrupt those that are doing it"
I'm understanding and expecting it won't cure me, but i'm hoping just for an increase in quality of life tbh. im hoping to do your protocol on TRT and see what happens. like the fasting, juicing, IF/, water fasting, paleo diet.
26, got my T checked throughout the years:
at the start it was below the range, then it became just low and im awaiting some more bloodwork to see if it qualifies as low still.
We can play the linking studies game all day if we want to:
Minoxidil INCREASES 5 alpha-reductase activity of cultured human dermal papilla cells from balding scalp
Topical minoxidil does not act as an antiandrogen in the flank organ of the golden Syrian hamster
As one of the studies above mentions, many NOW believe the mechanism of action for Minoxidil to be its prostaglandin activity (not its potential 5AR activity) that helps with hair loss:
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
Activation of ... prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effect
And from this paper: Minoxidil: mechanisms of action on hair growth - PubMed
A number of in vitro effects of minoxidil have been described in monocultures of various skin and hair follicle cell types including stimulation of cell proliferation, inhibition of collagen synthesis, and stimulation of vascular endothelial growth factor and prostaglandin synthesis.
Regardless there are many men who r sufering from 'pfs' just from minoxidil. https://www.askapatient.com/viewrati...+%28FOR+MEN%29
thats only dating back from 2020, theres far more people from 2015 but the old ones get pushed down. its really tragic
My guess is that many of these users were also prescribed Finasteride and don't realize that Finasteride is the cause of their lasting effects.
For instance:
i wish i had not taken this drug. finasteride gave me side effects but i recovered with minox its been 3wks and no change. i used to watch prn everyday but now im afraid because its difficult to have an erection. my only hope is my libido would return.Basically they stopped finasteride, but continued on minoxidil, and now attribute their long lasting PFS symptoms to minoxidil.I had a similar issue with finasteride and sexual function, however after a week I was pretty much back to normal. No idea what's happened this time but im really scared that I've done damage for good this time.