Biatch following the protocol

[biatch]

Since I reported a lot of negativity last week, (caused by panic) I would like to report that Yesterday was a "perfect day" regarding all sides, phisically, mentally, mood and sexually... So, yes, it's just a rollercoaster up and down for the moment but something is working back on the "real track of real life" and that makes me really happy and full of hope and wish to improve more and more...

[TubZy]

Since I reported a lot of negativity last week, (caused by panic) I would like to report that Yesterday was a "perfect day" regarding all sides, phisically, mentally, mood and sexually... So, yes, it's just a rollercoaster up and down for the moment but something is working back on the "real track of real life" and that makes me really happy and full of hope and wish to improve more and more...

You need to remember that PFS is literally an anxiety induced shit hole. Everything seems way overwhelming then it should be and trying new things sound like the scariest shit (I had this originally with caffeine, if I even thought of taking it my anxiety would sky rocket even worse, but once I had an idea of what was actually going in my body, that thought faded away and can tolerate more than I could ever now even prior to PFS), you literally need to tell yourself what is going with your body.

Once you start trying more and more stuff and seeing improvement it gets much easier once you actually understand what is going on your body. I.E. known that your GABA is severely impaired and that is causing your anxiety and know why its happening etc, that will make it much easier, instead of constantly guessing and assuming, which once again will lead to more anxiety

[jacknap]

You need to remember that PFS is literally an anxiety induced shit hole. Everything seems way overwhelming then it should be and trying new things sound like the scariest shit (I had this originally with caffeine, if I even thought of taking it my anxiety would sky rocket even worse, but once I had an idea of what was actually going in my body, that thought faded away and can tolerate more than I could ever now even prior to PFS), you literally need to tell yourself what is going with your body.

Once you start trying more and more stuff and seeing improvement it gets much easier once you actually understand what is going on your body. I.E. known that your GABA is severely impaired and that is causing your anxiety and know why its happening etc, that will make it much easier, instead of constantly guessing and assuming, which once again will lead to more anxiety

is it gaba or is it allopregnanalone though or both? a buddy of mine experienced a pharmaceutical recovery by using hydrocortisone + remeron. now he just uses remeron which apparently upregulated allopregnanalone

[TubZy]

is it gaba or is it allopregnanalone though or both? a buddy of mine experienced a pharmaceutical recovery by using hydrocortisone + remeron. now he just uses remeron which apparently upregulated allopregnanalone

Allopreg is a positive modulator of GABA-A so allopreg (and THDOC) are not modulating GABA as they should be, i.e. in reference to stress, anxiety, sleep etc.

The depleted neurosteroids is the source (from low 5AR I in the CNS), the GABA absence is just further down the chain.

Funny you brought up, Mirtazapine (remeron) is probably one of the last few things on my last that I haven't tried yet, it is pretty expensive. It does elevate neurosteroids pretty well and lowers adrenalin and pro thyroid, check out the links below. It is probably the only anti depressant "type" drug that I would consider trying (Peat considers it useful in certain situations, which I was surprised about) it has some similar benefits to androsterone (R-andro), but again I'm not condoning its use just like to show the research. Another member on Peat said they recovered using it.

https://raypeatforum.com/community/t...-others.15646/
https://raypeatforum.com/community/t...enaline.12425/
https://raypeatforum.com/community/t...ortisol.15626/
https://raypeatforum.com/community/t...chanism.16991/

[jacknap]

Allopreg is a positive modulator of GABA-A so allopreg (and THDOC) are not modulating GABA as they should be, i.e. in reference to stress, anxiety, sleep etc.

The depleted neurosteroids is the source (from low 5AR I in the CNS), the GABA absence is just further down the chain.

Funny you brought up, Mirtazapine (remeron) is probably one of the last few things on my last that I haven't tried yet, it is pretty expensive. It does elevate neurosteroids pretty well and lowers adrenalin and pro thyroid, check out the links below. It is probably the only anti depressant "type" drug that I would consider trying (Peat considers it useful in certain situations, which I was surprised about) it has some similar benefits to androsterone (R-andro), but again I'm not condoning its use just like to show the research. Another member on Peat said they recovered using it.

https://raypeatforum.com/community/t...-others.15646/
https://raypeatforum.com/community/t...enaline.12425/
https://raypeatforum.com/community/t...ortisol.15626/
https://raypeatforum.com/community/t...chanism.16991/

thanks for the links. do you think you can eventually cycle off remeron by a taper and maintain? Comedian Ari Shaffir also got PFS and he used disapramine and cycled off and doesn't use it anymore.

Dr. Mark Gordon also treats PFS like a TBI and recovered people using bioidentical hormones. Not sure if they have to stay on it for life or not. Do you think PFS is a type of TBI or is it more of a downregulation of receptors?

I've found relief using pregnanalone. Mostly for sleep/anxiety. Still wake up though 3-5 times a night and had to up my dose after using it for a week so I don't know if it's the answer either.

I believe I have most likely have a form of PFS but mine was caused by RU58841 and that's an anti-androgen so I think it would hit all the DHT receptors and even testosterone. from what you know think there's a slightly different game plan I should follow as it might be a bit of a different monster?

I posted my bloodwork on introduce yourself section if you could have a look. I had low FSH, low LH, high cortisol, low free T, high DHT, very high SHBG, medium T, medium estrogen (Canadian/European metrics)

I had sides from RU for 16 days after one topical application. Then my T came back with a vengeance but during the upswing I used modafinil twice, lsd once, and binge drank twice. Also a lot of sex and masturbation. So my functional medicine doctor thinks I might have fried my NMDA receptors possibly. Not totally ruling that out either. crashed like 5 weeks after that one time application of ru.

[TubZy]

thanks for the links. do you think you can eventually cycle off remeron by a taper and maintain? Comedian Ari Shaffir also got PFS and he used disapramine and cycled off and doesn't use it anymore.

Dr. Mark Gordon also treats PFS like a TBI and recovered people using bioidentical hormones. Not sure if they have to stay on it for life or not. Do you think PFS is a type of TBI or is it more of a downregulation of receptors?

I've found relief using pregnanalone. Mostly for sleep/anxiety. Still wake up though 3-5 times a night and had to up my dose after using it for a week so I don't know if it's the answer either.

I believe I have most likely have a form of PFS but mine was caused by RU58841 and that's an anti-androgen so I think it would hit all the DHT receptors and even testosterone. from what you know think there's a slightly different game plan I should follow as it might be a bit of a different monster?

I posted my bloodwork on introduce yourself section if you could have a look. I had low FSH, low LH, high cortisol, low free T, high DHT, very high SHBG, medium T, medium estrogen (Canadian/European metrics)

I had sides from RU for 16 days after one topical application. Then my T came back with a vengeance but during the upswing I used modafinil twice, lsd once, and binge drank twice. Also a lot of sex and masturbation. So my functional medicine doctor thinks I might have fried my NMDA receptors possibly. Not totally ruling that out either.

You are similar to me, I used both fin and RU. I only used RU for a small period of time after stopping fin, but during my two year use on fin, I felt like absolute crap and it continued after quitting (after quitting I felt the same exact way as I did while on). During the short time I used RU, I felt even worse, but if I would stop I would feel better in a day or two so I don't think it is RU related, it just increased symptoms even worse. If it was strictly RU related, about any AR agonist (preg is an AR agonist) would fix it.

If you read through my posts you will see I think preg and prog both have their places and I got superior results from high dose preg originally which subsided after a couple of weeks, which I assume to be now from in increase in androgens or the lowering of estrogen.

Regarding the drugs/supplements, no I don't think you need to be on them for life or anything like that. Your body has a positive feedback mechanism so if you are increasing certain biodentical hormones, your body is going to produce more of the enzymes associated with those hormones over time. It is shown in many studies, i.e. adding in bioidentical DHT increases 5AR, adding in pregnenolone increases the enzymes associated for metabolizing preg etc.

Same reason why people have been recovering after repetitive R andro cycles, as the enzymes associated with metabolizing androsterone are all increased.

Oh and to your last question, no I don't think receptors have anything to do with it anymore (I originally did about 2 years ago)

[jacknap]

You are similar to me, I used both fin and RU. I only used RU for a small period of time after stopping fin, but during my two year use on fin, I felt like absolute crap and it continued after quitting (after quitting I felt the same exact way as I did while on). During the short time I used RU, I felt even worse, but if I would stop I would feel better in a day or two so I don't think it is RU related, it just increased symptoms even worse. If it was strictly RU related, about any AR agonist (preg is an AR agonist) would fix it.

If you read through my posts you will see I think preg and prog both have their places and I got superior results from high dose preg originally which subsided after a couple of weeks, which I assume to be now from in increase in androgens or the lowering of estrogen.

Regarding the drugs/supplements, no I don't think you need to be on them for life or anything like that. Your body has a positive feedback mechanism so if you are increasing certain biodentical hormones, your body is going to produce more of the enzymes associated with those hormones over time. It is shown in many studies, i.e. adding in bioidentical DHT increases 5AR, adding in pregnenolone increases the enzymes associated for metabolizing preg etc.

Same reason why people have been recovering after repetitive R andro cycles, as the enzymes associated with metabolizing androsterone are all increased.

Oh and to your last question, no I don't think receptors have anything to do with it anymore (I originally did about 2 years ago)

wow thanks for that. yeahI'm 90% sure it's strictly RU related AND/OR could be NMDA receptor damage from using strong stimulants during androgen deprivation causing possible glutamate toxicity cause I didn't have enough gaba to downregulate it?

i think the nmda receptor theory might be farfetched though because even after using LSD and modafinil before the crash I had a few days of normalcy.

so approaching it as a strictly RU problem would remeron alone or pregnanalone alone or R-andro alone be enough to recover? what kinda time frame we talking running it? 30 days? 90 days? 6 months? a year? two years?

i'm looking into doing a water fast ala cdnuts as well but I'm still slim 160lbs 6' 8-14% bodyfat. Still pretty muscular squat 200, dead 320 one rep maxes

I used 1ml 50mg RU one time and got sides right away and stopped and I'm like a norwood 1 so might have just went straight through my blood brain barrier. I was losing hair like crazy though so took it as a preventative and was persuaded by it's presumed safety compared to fin.

curious what your full protocol is and other things you found pivotal besides the b3, vitamin c, caffeine