PFS = Adrenal Fatigue

[Karlucchi]

This has been my theory as well for a long time. I've come to the conclusion that in order to fix the problem that is Adrenal Fatique, we have to fix the underlying issue that created the problem. That is the lack of neurosteroids that modulate our stress response to stressors. I'm sure most of us know that people with PFS have been shown to have chronically low Allopregnanolone which is a positive allosteric modulator of the GABAA.

Just in case anyone wants to read into ALLO and what it does for us
https://www.frontiersin.org/articles...020.00236/full

Chronic stress has been shown to lower BDNF, stopping the brain from healing any damage that has been done to it.
Androsterone also acts as a neurosteroid and positive allosteric modulator of GABAA.

My current strategy to heal is to take Alpha Seven (200 mg of Androsterone) while taking Semax (to raise BDNF) and NAD+ nasally administered to heal the brain.

I've been using the Semax with Pine Pollen for a couple weeks now and it has DEFINITELY helped my stress response. I'm excited to add in a higher dose of Andro and the NAD+ which has been reported to help people with CFS/chronic stress recover.

[jacknap]

This has been my theory as well for a long time. I've come to the conclusion that in order to fix the problem that is Adrenal Fatique, we have to fix the underlying issue that created the problem. That is the lack of neurosteroids that modulate our stress response to stressors. I'm sure most of us know that people with PFS have been shown to have chronically low Allopregnanolone which is a positive allosteric modulator of the GABAA.

Just in case anyone wants to read into ALLO and what it does for us
https://www.frontiersin.org/articles...020.00236/full

Chronic stress has been shown to lower BDNF, stopping the brain from healing any damage that has been done to it.
Androsterone also acts as a neurosteroid and positive allosteric modulator of GABAA.

My current strategy to heal is to take Alpha Seven (200 mg of Androsterone) while taking Semax (to raise BDNF) and NAD+ nasally administered to heal the brain.

I've been using the Semax with Pine Pollen for a couple weeks now and it has DEFINITELY helped my stress response. I'm excited to add in a higher dose of Andro and the NAD+ which has been reported to help people with CFS/chronic stress recover.

this in a way is still looking at it in the symptom perspective imo. Allo is low because our body is trying to force us to rest because we've been ignoring the signal too long. NAD+ is a nutrient though so will probably help. A lot of people including myself found niacinamide to help which is similar.

[Karlucchi]

this in a way is still looking at it in the symptom perspective imo. Allo is low because our body is trying to force us to rest because we've been ignoring the signal too long. NAD+ is a nutrient though so will probably help. A lot of people including myself found niacinamide to help which is similar.

Allo is low because we destroyed the 5AR enzymes in our brain and it has struggled to rebuild them. Likely because of the level of stress our body had to take on with no Allo to modulate the response to it while the drug was active in our system.
Adrenal Fatigue is the symptom of low 5AR activity in the brain
Niacinamide helps many people because it upregulates 5AR in the brain.

I'm not debating if living a stress free life is a path towards recovery because I think it is. How long that recovery takes is what I don't know. I'm not sure how practical living a stress free life for an extended period of time is in our society.
I hope to find that the Semax and NAD+ is a way to shorten that recovery.

[jacknap]

Allo is low because we destroyed the 5AR enzymes in our brain and it has struggled to rebuild them. Likely because of the level of stress our body had to take on with no Allo to modulate the response to it while the drug was active in our system.
Adrenal Fatigue is the symptom of low 5AR activity in the brain
Niacinamide helps many people because it upregulates 5AR in the brain.

I'm not debating if living a stress free life is a path towards recovery because I think it is. How long that recovery takes is what I don't know. I'm not sure how practical living a stress free life for an extended period of time is in our society.
I hope to find that the Semax and NAD+ is a way to shorten that recovery.

the fact that most people do not lower their stress considerably because they put too much demands on themselves is a key reason why a lot of people struggle to recover from this. most people who get PFS crash (me included) note that it happened during a period of intense stress.

we don't know if 5ar in the brain is destroyed that's just a theory. could just be a forced down regulation because we keep red lining our bodies and lowering any kinda testosterone during a period of stress is the straw that broke the camels back so to speak. the body downregulates things like allo in order to get us to rest to rebuild reserves rather than it get 'destroyed' so to speak.

[Cambridge]

@Karlucchi, Where did you get your Semax from? I've read some reports that say the stuff manufactured in Russia is far superior, and then other reports say the opposite.