Quote Originally Posted by Karlucchi View Post
This has been my theory as well for a long time. I've come to the conclusion that in order to fix the problem that is Adrenal Fatique, we have to fix the underlying issue that created the problem. That is the lack of neurosteroids that modulate our stress response to stressors. I'm sure most of us know that people with PFS have been shown to have chronically low Allopregnanolone which is a positive allosteric modulator of the GABAA.

Just in case anyone wants to read into ALLO and what it does for us
https://www.frontiersin.org/articles...020.00236/full

Chronic stress has been shown to lower BDNF, stopping the brain from healing any damage that has been done to it.
Androsterone also acts as a neurosteroid and positive allosteric modulator of GABAA.

My current strategy to heal is to take Alpha Seven (200 mg of Androsterone) while taking Semax (to raise BDNF) and NAD+ nasally administered to heal the brain.

I've been using the Semax with Pine Pollen for a couple weeks now and it has DEFINITELY helped my stress response. I'm excited to add in a higher dose of Andro and the NAD+ which has been reported to help people with CFS/chronic stress recover.
this in a way is still looking at it in the symptom perspective imo. Allo is low because our body is trying to force us to rest because we've been ignoring the signal too long. NAD+ is a nutrient though so will probably help. A lot of people including myself found niacinamide to help which is similar.